Nā pono o ka Capsule

I ka makahiki 1500 BC, ka muacapsuleua hānau ʻia ma ʻAigupita.

I ka makahiki 1730, hoʻomaka nā lāʻau lapaʻau ma Vienna e hanacapsulesmai ka starch.

I ka makahiki 1834,capsuleua hoʻopaʻa ʻia ka ʻenehana hana ma Paris.

I ka makahiki 1846, paakiki ka pauku eluacapsuleua loaʻa ka ʻenehana hana ma Farani Patents.

I ka makahiki 1848, ʻelua ʻāpanacapsulespuka mai.Mai ia manawa mai,Haʻahaʻa nā pūpū capsule paʻakikīua komo i loko o ka honua lapaʻau a lilo i pahu pahu lāʻau lapaʻau.

I ka makahiki 1874, ʻo ka hana ʻoihana ʻoihana paʻakikīcapsules(Hubel) ua hoʻomaka ʻia ma Detroit, a ua hoʻokomo ʻia nā hiʻohiʻona like ʻole i ka manawa like.

I ka makahiki 1888, ua loaʻa iā Parke-Davis kahi patent no ka hana ʻananā capsules paʻakikīma Detroit (JB Russell)

I ka makahiki 1931, ua hana ʻo Parke-Davis.capsuleʻO ka wikiwiki hana i hiki i 10,000capsulesi kēlā me kēia hola (A. Colton)

Ma ke ʻano he lāʻau lapaʻau kūpono,Haʻahaʻa nā pūpū capsule paʻakikīhoʻohana nui ʻia i ka hoʻomākaukau lāʻau.Hāʻawi nui ʻia lākou i ka pauka, wai, semi-solid, ʻaila, papa a me nā mea hoʻomākaukau ʻē aʻe.Hiki iā lākou ke hoʻopau wikiwiki, hilinaʻi a me ka palekana.Loaʻa iā lākou nā pono penei:

1) Nani a maʻalahi ke ale.

2) Ka hopena masking: Hiki iā ia ke uhi i ka ʻawaʻawa ʻoluʻolu a me ke ʻala o ka lāʻau lapaʻau, a pale a hoʻopaʻa i nā mea paʻa ʻole.

3) Bioavailability kiʻekiʻe o ka lāʻau lapaʻau:Kāpenaʻaʻole koi i ka hoʻopili a me ke kaomi i ka wā o ka hoʻomākaukau ʻana e like me nā papa a me nā lāʻau, no laila e hoʻopuehu koke lākou a komo maikaʻi i ka ʻōpū a me ka ʻōpū.

4) ʻOi aku ka maikaʻi o ka pale ʻana i nā huahana lāʻau: Me ka loaʻa ʻole o ke kiʻekiʻe kiʻekiʻe a me ke kaomi kiʻekiʻe i lawe ʻia e ka papa paʻi papa, ke ʻano kūlohelohe o nā mea kanu lāʻau lapaʻau i kacapsulehiki ke mālama.

5) Hiki ke hana ʻia i hoʻomākaukau hoʻokuʻu hoʻomau a me nā hoʻomākaukau pūhui:

Hiki ke hoʻokuʻu ʻia ka lāʻau i ka manawa a me kahi (enteric-coated, pulsed a me nā ʻōnaehana hoʻokuʻu lāʻau ʻē aʻe).Inā hana mua ʻia ka lāʻau lapaʻau i loko o nā ʻāpana, a laila hoʻohana ʻia nā mea waiwai gelatin a me nā mea me nā helu hoʻokuʻu like ʻole, hiki ke hoʻokō ʻia ka hopena o ka manawa a me ka hoʻokuʻu kūlana.No laila,capsulesʻO nā ʻano mea hoʻohana kūpono no ka hoʻomohala ʻana i nā hoʻomākaukau hoʻokuʻu hoʻomau a me nā hoʻomākaukau hui.

6) He maʻalahi ka papa kuhikuhi a me ka hoʻomākaukau ʻana, kūpono no ka ʻoihana a me ka hana automation.