Nā pono o ka Capsule

I ka makahiki 1500 BC, ua hānau ʻia ka capsule mua ma ʻAigupita.

I ka makahiki 1730, ua hoʻomaka nā lāʻau lapaʻau ma Vienna e hana i nā capsules mai ka starch.

I ka makahiki 1834, ua patent ʻia ka ʻenehana hana capsule ma Paris.

I ka makahiki 1846, ua loaʻa ka ʻenehana hana ʻenehana paʻakikī paʻakikī ʻelua ma Farani Patents.

I ka makahiki 1848, ua puka mai na capsule elua. Mai ia manawa mai, ua komo ka Empty hard capsule shells i ka honua lapaʻau a lilo i mau pahu pahu lāʻau lapaʻau.

I ka makahiki 1874, ua hoʻomaka ʻia ka hana ʻoihana o nā capsules paʻakikī (Hubel) ma Detroit, a ua hoʻokomo ʻia nā ʻano hiʻohiʻona like ʻole i ka manawa like.

I ka makahiki 1888, ua loaʻa iā Parke-Davis kahi patent no ka hana ʻana i nā capsule paʻakikī ma Detroit (JB Russell)

I ka makahiki 1931, ua hiki i ka 10,000 capsules i ka hora (A. Colton) ka wikiwiki o ka hana ana o Parke-Davis.

Ma ke ʻano he lāʻau lapaʻau maikaʻi loa, hoʻohana nui ʻia nā pūpū ʻo Empty hard capsule i nā hoʻomākaukau lāʻau. Hāʻawi nui ʻia lākou i ka pauka, wai, semi-solid, ʻaila, papa a me nā mea hoʻomākaukau ʻē aʻe. Hiki iā lākou ke hoʻopau wikiwiki, hilinaʻi a me ka palekana. Loaʻa iā lākou nā pono penei:

1) Nani a maʻalahi ke ale.

2) Ka hopena masking: Hiki iā ia ke uhi i ka ʻawaʻawa ʻoluʻolu a me ke ʻala o ka lāʻau lapaʻau, a pale a hoʻopaʻa i nā mea paʻa ʻole.

3) Bioavailability kiʻekiʻe o ka lāʻau lapaʻau: ʻAʻole pono nā Capsules i ka hoʻopili a me ke kaomi i ka wā o ka hoʻomākaukau ʻana e like me nā papa a me nā pila, no laila e hoʻopuehu koke lākou a komo maikaʻi i ka ʻōpū a me ka ʻōpū.

4) ʻOi aku ka maikaʻi o ka pale ʻana i nā mea kanu lāʻau: Me ka ʻole o ke kiʻekiʻe kiʻekiʻe a me ke kaomi kiʻekiʻe i lawe ʻia e ka papa paʻi papa, hiki ke mālama ʻia ke kūlana kūlohelohe o nā mea kanu lāʻau i loko o ka capsule.

5) Hiki ke hana ʻia i hoʻomākaukau hoʻokuʻu hoʻomau a me nā hoʻomākaukau pūhui:

Hiki ke hoʻokuʻu ʻia ka lāʻau i ka manawa a me kahi (enteric-coated, pulsed a me nā ʻōnaehana hoʻokuʻu lāʻau ʻē aʻe). Inā hana mua ʻia ka lāʻau lapaʻau i loko o nā ʻāpana, a laila hoʻohana ʻia nā mea waiwai gelatin a me nā mea me nā helu hoʻokuʻu like ʻole, hiki ke hoʻokō ʻia ka hopena o ka manawa a me ka hoʻokuʻu kūlana. No laila, ʻo nā capsules he mau ʻano dosage kūpono no ka hoʻomohala ʻana i nā hoʻomākaukau hoʻokuʻu hoʻomau a me nā hoʻomākaukau hoʻohui.

6) He maʻalahi ka papa kuhikuhi a me ka hoʻomākaukau ʻana, kūpono no ka ʻoihana a me ka hana automation.